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KMID : 0371320050680040288
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Journal of the Korean Surgical Society
2005 Volume.68 No. 4 p.288 ~ p.295
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Tumor Necrosis Factor-α-308G/A Promoter Polymorphism is Associated with the Severity of Gastric Carcinomas
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Kim Woon-Woo
Hong Kwan-Hee
Jang Won-Hee
Kim Hyeong-In
Seo Ji-Yeon
Yang Young-Il
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Abstract
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Purpose: The pro-inflammatory cytokine, tumor necrosis factor-α (TNF-α), is a central mediator of the immune response involved in a wide range of immuno-inflammatory and infectious diseases. There is increasing evidence that TNF-α may promote the development and spread of the cancer. Polymorphisms in the TNF-α promoter have been related to TNF-α production. Therefore, we investigated the potential association of TNF-α genotypes with gastric cancer in the Korean population.
Methods: The study included 66 patients with gastric adenoma, 75 patients with gastric carcinoma, and 551 healthy controls. The -308 and -238 polymorphisms in the TNF-α promoter were analyzed by PCR- restriction fragment length polymorphism (RFLP). Distributions of TNF-α promoter polymorphisms were compared between groups byχ2 test. P values smaller than 0.05 were considered to be significant.
Results: The proportion of individuals carrying the TNF-α -308A allele was higher in the carcinoma group compared to controls and adenomas, but the differences were not significant (P=0.124). However, the TNF-α -308A allele was significantly associated with advanced gastric carcinoma (P=0.026), serosa invasion (P=0.004), neural invasion (P= 0.021), and lymph node metastasis (P=0.005). On the other hand, the TNF-α -238G/A polymorphism was not associated with the development of gastric adenoma and carcino ma and the severity of gastric carcinoma.
Conclusion: These results suggest that the TNF-α -308A allele is associated with the severity of gastric carcinoma in terms of invasion and metastasis in the Korean population. Therefore, TNF-α promoter polymorphism could be used as a predictive marker of the severity of gastric carcinoma.
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KEYWORD
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Gastric cancer, Progression, TNF-α, Promoter polymorphism
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